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How much wedge does it take to make a guitar comfortable? Im thinking anything larger than an OM, smaller than a jumbo. would a 1/2" be enough?

If, by 1/2", you mean adding that much depth to one side, and reducing the other by the same amount, that works well. It's not all that much, but it makes about the same difference in comfort as reducing the width of the lower bout by about an inch. So far as I can tell it makes no real difference in the sound.

I'm just started a wedge gutar build and have been looking at info on this myself - this post makes a similar suggestion to Alan's.
http://www.luthiersforum.com/forum/viewtopic.php?f=10102&t=2141&p=18080&hilit=wedge+inch+manzer#p18080
This post http://www.luthiersforum.com/forum/viewtopic.php?f=10101&t=22794&p=312398&hilit=wedge+inch+manzer#p312398
shows a wedged SJ build made by our very own Fred Tellier at 7/8" difference between treble to bass sides.

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The name catgut is confusing. There are two explanations for the mix up.

Catgut is an abbreviation of the word cattle gut. Gut strings are made from sheep or goat intestines, in the past even from horse, mule or donkey intestines.

Otherwise it could be from the word kitgut or kitstring. Kit meant fiddle, not kitten.

Just to come back to this question, any wedge will make a guitar "more comfortable", it's surprising how little makes a difference.
A while ago, I made 2 OMs at the same time, and wedged one by about 1/8" total from side to side for an older beginner - it was noticably more comfy under the arm, so it depends what you are looking for.
So to answer the question, perhaps I should say - 1/2" would be enough to make a guitar noticably more comfortable, without the technical difficulties imposed by what is seen as the the full/normal/standard Manzer wedge.

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The name catgut is confusing. There are two explanations for the mix up.

Catgut is an abbreviation of the word cattle gut. Gut strings are made from sheep or goat intestines, in the past even from horse, mule or donkey intestines.

Otherwise it could be from the word kitgut or kitstring. Kit meant fiddle, not kitten.